产品详情
产品名称presenilin 1 Mouse Polyclonal Antibody FITC Conjugated
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Purified by Protein A.
应用IF(IHC-P)
种属反应性Hu Rt Rb
免疫原描述KLH conjugated synthetic peptide aa 1-50 467 derived from rat presenilin 1
基因/蛋白名称presenilin 1
标记FITC
激发/发射波长494nm 518nm
别名Presenilin-1; PS-1; Protein S182; Psen1; Psnl1
浓度1mg ml
配方10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% sodium azide.
保存 Store at 4C for 12 months.
应用详情
Immunofluorescence: 1:50-200
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).
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货期15天
