产品详情
产品名称Cyclin D1 Antibody HRP Conjugated
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Purified by Protein A.
应用WB IHC-P
种属反应性Hu Ms Rt Goat
免疫原描述KLH conjugated synthetic peptide aa 70-120 295 derived from mouse Cyclin D1
基因/蛋白名称Cyclin D1
标记HRP
激发/发射波长N A
别名cD1; CycD1; Cyl-1; PRAD1; bcl-1; AI32739; G1 S-specific cyclin-D1; Ccnd1
数据库入口号Swiss-Prot#P25322
NCBI Gene ID12443
Uniprot
P25322
浓度1mg ml
配方10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% Gentamicin.
保存 Store at 4C for 12 months.
应用详情
Western blotting: 1:100-1000
Immunohistochemistry1:100-500
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1) S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1 CDK4 CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity).
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et al,Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl?2?like protein 11 and cyclin?dependent kinase inhibitor 1B Mol Med Rep. On 2018 Feb by Yan F, Liao R et al..PMID: 29257235
, (2018),
PMID:
29257235
货期15天
