产品详情
产品名称Tau (Phospho-Thr181) Conjugated Antibody
来源种属Rabbit
克隆性Polyclonal
应用WB, IF
种属反应性Hu Ms Rt
特异性The antibody detects endogenous level of Tau only when phosphorylated at threonine 181.
免疫原描述Peptide sequence around phosphorylation site of threonine 181 (P-K-T(p)-P-P) derived from Human Tau.
标记AF荧光素
激发/发射波长AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm
别名MAPT;MTAPT;MTBT1;Neurofibrillary tangle protein;PHF-tau
数据库入口号Swiss-Prot#:P10636
NCBI Gene ID:4137
NCBI mRNA#:NM_001123066.2
NCBI Protein#: NP _001116538.1
Uniprot
P10636
计算分子量48 62 78
配方0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
保存Store at 4˚C in dark for 6 months
应用详情
WB: 1:50-1:200
IF:1:50-1:200
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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et al,Cerebrospinal Fluid of Patients With Alzheimer's Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles
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PMID:
34295239
et al,Fingolimod ameliorates amyloid deposition and neurodegeneration in APP/PS1 mouse model of Alzheimer's disease.
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PMID:
40158900
1-2 weeks
