Cas1036915-08-8

产品名称IDX184

别名IDX 184;IDX184;IDX-184;HCV NS5B polymerase;HCV Protease;HCVProtease

计算分子量626.62

保存store at low temperature . Powder: -20°C for 3 years . In solvent: -80°C for 1 year . Shipping with blue ice.

分子式:C25H35N6O9PS
Smile:C[C@]1(O)[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(NCC4=CC=CC=C4)(OCCSC(C(CO)(C)C)=O)=O)[C@H]1O
DML号:MFCD23381633
纯度:99.29%
溶解度:DMSO:50 mg/mL (79.79 mM)
体外活性:IDX184, a liver-targeted prodrug of the nucleotide 2′-MeG-MP, serves as a hepatitis C virus polymerase inhibitor with liver-specific targeting.[1] IDX184 is not toxic (CC50>100μM) in any tested cell line.[2] IDX184 is a second-generation, orally bioavailable nucleotide prodrug designed to provide increased anti-HCV efficacy and safety versus the parent nucleoside. In HCV replicon testing, IDX184 is the most potent inhibitor (EC50=0.3-0.45 μM) compared to any of the 2’ or 4’ modified nucleosides (EC50=4-6 μM) and is also highly inhibitory in the JFH-1 infectious system (EC50=0.06-0.11 μM).[2]
靶点活性:HCV polymerase:0.31 μM (IC50)|HCV polymerase:52.3 nM (Ki)
信号通路:蛋白酶体|微生物学
靶点:HCV Protease