Cas202914-18-9

产品名称Indantadol HCl

别名Indantadol;Indantadol HCl;Indantadol hydrochloride;GT 3381;GT3381;MAO;NMDA;CHF3381;CHF-3381;CHF 3381;CNP 3381;CNP3381;CMP 3381;CMP3381;V3381;V 3381

计算分子量226.7

保存Powder: -20°C for 3 years . In solvent: -80°C for 1 year . Shipping with blue ice.

分子式:C11H15ClN2O
Smile:Cl.O=C(N)CNC1CC=2C=CC=CC2C1
DML号:MFCD09840800
纯度:98.24%
溶解度:DMSO:50 mg/mL (220.56 mM)
体内活性:In a human heat-capsaicin-induced pain model, Indantadol HCl at a dose of 500 mg effectively reduced the area of secondary hyperalgesia to 67%. Indantadol HCl undergoes extensive liver metabolism, withthe formation of two major metabolites - CHF-3567 and 2-aminoindane. The drug is excreted in urine partially as the parent compound, but mostly as CHF-3567. The tolerability profile of Indantadol HCl at single doses up to 600 mg and twice-daily doses up to 400 mg in clinical trials was significantly more favorable than for other NMDA antagonists. Most side effects have been observed to be mild, and include dizziness and asthenia. Indantadol HCl is currently in phase II clinical trials in patients with diabetic peripheral neuropathic pain.[1]
信号通路:代谢|神经科学|神经科学
靶点:MAO|NMDAR