Cas500164-74-9

产品名称IP7e

别名brain-penetrant;orally;NF-kB;Nurr1;Inhibitor;inhibit;isoxazolo-pyridinone 7e;IP7e;IP-7e;IP 7e

计算分子量390.43

保存Powder: -20°C for 3 years . In solvent: -80°C for 1 year . Shipping with blue ice.

分子式:C23H22N2O4
Smile:COCCOCc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
DML号:MFCD30182349
纯度:98.54%
溶解度:DMSO:95 mg/mL (243.32 mM)
体内活性:IP7e(10 mg/kg) attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process. IP7e preventive treatment reduces the incidence and the severity of an MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE)[1].
靶点活性:Nurr1:3.9 nM(EC50)
信号通路:其他
靶点:Others