Cas19685-09-7

产品名称(S)-10-Hydroxycamptothecin

别名p53;PCNA;G2/M;c-Myc;Cell-cycle;10-HCPT;10-Hydroxycamptothecin;10-羟基喜树碱;10-羟喜树碱;(S)10Hydroxycamptothecin;(S) 10 Hydroxycamptothecin;Bcl-2;Bax;Apoptosis;arrest;antitumor;caspase-1/3r;Topoisomerase;Topo I

计算分子量364.35

保存Powder: -20°C for 3 years . In solvent: -80°C for 1 year . Shipping with blue ice.

分子式:C20H16N2O5
Smile:O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=C(O)C4)=CC5=C1COC(=O)[C@@]5(CC)O
DML号:MFCD02093100
纯度:99.48%
溶解度:H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:20 mg/mL (54.89 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)
体内活性:在BT-20细胞（IC50=34.3 nM）和MDA-231细胞（IC50=7.27 nM）中,(S)-10-Hydroxycamptothecin抑制细胞生长。在pBR322质粒DNA中（EC50=0.35 μM）, (S)-10-Hydroxycamptothecin有效诱导的人拓扑异构酶I介导的易解离复合物的形成。在人微血管内皮细胞（HMEC）中,(S)-10-Hydroxycamptothecin能够剂量依赖性的抑制细胞生长（IC50=0.31 μM）,显着抑制HMEC的迁移（IC50=0.63 μM）,抑制血管形成（IC50=0.96 μM）。
体外活性:在CAM模型中,10-Hydroxycamptothecin（25 nM）以浓度依赖性方式抑制血管生成.在携带有Colo 205异种移植物小鼠中,每2天口服10-Hydroxycamptothecin（2.5-7.5 mg / kg）,能够显著抑制肿瘤细胞生长.
细胞实验:Cells are exposed to various concentrations of 10-Hydroxycamptothecin for 72 hours. Cell growth is monitored by the standard MTT assay.(Only for Reference)
信号通路:凋亡|DNA 损伤和修复
靶点:Apoptosis|Topoisomerase