Cas20702-77-6

产品名称Neohesperidin Dihydrochalcone

别名inhibit;Inhibitor;NCI-c60764;ReactiveOxygenSpecies;Reactive Oxygen Species;Neohesperidin DC;Neohesperidin Dihydrochalcone;NHDC;新橙皮苷二氢查尔酮;新橙皮苷二氢查耳酮

计算分子量612.58

保存keep away from direct sunlight . Powder: -20°C for 3 years . In solvent: -80°C for 1 year . Shipping with blue ice.

分子式:C28H36O15
Smile:O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)[C@@H](O)[C@H](O)[C@@H](CO)O1)C3=CC(O)=C(C(CCC4=CC(O)=C(OC)C=C4)=O)C(O)=C3
DML号:MFCD00017711
纯度:99.8%
溶解度:DMSO:50 mg/mL (81.62 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:100 mg/mL (163.24 mM)
体内活性:Neohesperidin dihydrochalcone的给药显著减少了肝损伤的两种有用标志物AST和ALT的活性。在PQ处理的小鼠中，NF-κB、IL-6、IL-1β和TNF-α蛋白的相对水平受到Neohesperidin dihydrochalcone的抑制[3]。对Wistar Crl:(WI)WU BR大鼠进行的Neohesperidin dihydrochalcone的胚胎毒性/致畸性研究显示，在最高剂量水平下饮食中Neohesperidin dihydrochalcone含量高达5%，相当于大鼠每日约摄入3.3 g/kg体重，未观察到不良影响[4]。
细胞实验:WST-8 dye is used in the cell viability assay. HIT-T15 and HUVEC cells are grown and maintained in Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine calf serum. 1000 cells in each well are incubated with various concentrations of neohesperidin dihydrochalcone (50, 100, 500 μM, 1 mM) and other compounds. After treating HIT-T15 and HUVEC cells with 500 μM HOCl, WST-8 dye is added to each well, and the absorbance is detected at 420 nm with microplate reader[1].
信号通路:代谢|NF-κB 信号通路|免疫与炎症
靶点:Reactive Oxygen Species