Cas1680193-80-9

产品名称JZP-361

别名JZP361;JZP-361;JZP 361;MAGL

计算分子量405.88

保存Powder: -20°C for 3 years . In solvent: -80°C for 1 year . Shipping with blue ice.

分子式:C22H20ClN5O
Smile:Clc1ccc2c(CCc3cccnc3C2=C2CCN(CC2)C(=O)n2cncn2)c1
DML号:MFCD30536369
纯度:99.41%
溶解度:Ethanol:36.5 mg/mL (89.93 mM);DMSO:1 mg/mL (2.46 mM)
体外活性:JZP-361表现出与H1拮抗剂的亲和力，具有6.81的pA2值。JZP-361（≤10 μM）未显示大麻素受体活性。JZP-361在羰基氧与氧阴离子孔的重要氢键作用中显示出有利的相互作用[1]。
靶点活性:ABHD6 (human):1.79 μM|FAAH (human):7.24 μM|MAGL (human):46 nM|H1 receptor:6.81 (pA2)
信号通路:代谢
靶点:Lipase