产品详情
产品名称Wee1B Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用Custom antibody
种属反应性Mouse
免疫原类型Peptide-KLH
基因/蛋白名称Wee1B
标记Unconjugated
别名Wee1-like protein kinase 1B; Wee2
数据库入口号uniprot:Q66JT0
Uniprot
Q66JT0
计算分子量62kDa
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
应用详情
Western blotting: 1:500~1:1000
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry.
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et al,Promotion effect of down-regulation of protein kinase Wee1B expression on mitosis of mouse one-cell-stage embryos
, (2014),
PMID:
Yes
