产品详情
产品名称OGT (Phospho-Ser20) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用Custom antibody
种属反应性Human;Mouse
免疫原类型Peptide-KLH
基因/蛋白名称OGT
标记Unconjugated
别名UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
数据库入口号uniprot:O15294
计算分子量117kDa
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 126% glycerol.
保存Store at -20��C for long term preservation (recommended). Store at 4��C for short term use.
应用详情
Western blotting: 1:500~1:1000
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:26678539, PubMed:23103939, PubMed:21240259, PubMed:21285374, PubMed:15361863). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (PubMed:26678539).
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et al,Targeting cTRIP12 counteracts ferroptosis resistance and augments sensitivity to immunotherapy in pancreatic cancer.
, (2025),
PMID:
40154160
Yes
