产品详情
产品名称PGC-1a (Mono-methyl-K224) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was purified from rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
应用WB
种属反应性Human
特异性PGC-1a (Mono-methyl-K224) Antibody detects endogenous levels of PGC-1a only when mono-methylated at lysine 224.
免疫原描述A synthesized peptide derived from human PGC-1a around the mono-methylation site of K224.
标记Unconjugated
别名PGC-1-alpha,
PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6,LEM6, PGC1, PGC1A, PPARGC1
Uniprot
Q9UBK2
Gene ID
10891
实际分子量91kDa
浓度1 mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM
NaCl,0.02% sodium azide and 50% glycerol.
保存Store at --20˚C/1 year
应用详情
Western Blot: 1/500 - 1/2000
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.
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et al,KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis
, (2019),
PMID:
31629659
Yes
