产品详情
产品名称COMP Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total COMP protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human COMP (NP_000086.2).
基因/蛋白名称COMP
标记Unconjugated
别名COMP;EDM1;EPD1;MED;PSACH;THBS5;TSP5
数据库入口号Uniprot:P49747
GeneID:1311
Uniprot
P49747
Gene ID
1311
实际分子量110KDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IF 1:10 - 1:100
Western blot analysis of extracts of various cell lines, using COMP antibody.
Western blot analysis of extracts of various cell lines, using COMP antibody.
Immunofluorescence analysis of Rat cartilage using COMP Rabbit pAb.
Immunofluorescence analysis of Mouse cartilage using COMP Rabbit pAb.
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
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et al,The molecular mechanism study of COMP involved in the articular cartilage damage of Kashin-Beck disease. In Bone Joint Res on 2020 Sep 20 by Mei Ma, Xiao Liang, et al..PMID:33005397
, (2020),
PMID:
33005397
et al,Electroacupuncture improves motor function of rats with osteoarthritis by alleviating joint inflammation through the Wnt-7B/β-catenin signaling pathwayInNan Fang Yi Ke Da Xue Xue BaoOn2023 Apr 20byX Zheng?1,?S Gao et al..PMID: 37202195
, (2023),
PMID:
37202195
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