产品详情
产品名称AIM2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB
种属反应性Human
特异性The antibody detects endogenous levels of total AIM2 protein.
免疫原类型Peptide
免疫原描述Synthesized peptide derived from internal of human AIM2.
基因/蛋白名称AIM2
标记Unconjugated
别名Interferon-inducible protein AIM2; Absent in melanoma 2; AIM2;
数据库入口号Swiss-Prot: O14862
NCBI Gene ID: 9447
Uniprot
O14862
实际分子量39kd
浓度1.0mg/ml
配方Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500~1:3000
Western blot analysis of extracts from HUVEC cells, using AIM2 antibody #34166.
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 By similarity. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
DeYoung K.L., Oncogene 15:453-457(1997).
Gregory S.G., Nature 441:315-321(2006).
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et al,Pyroptosis burden is associated with anti-TNF treatment outcome in inflammatory bowel disease: new insights from bioinformatics analysis
, (2023),
PMID:
37740137
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