产品详情
产品名称CTNNAL1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用WB
种属反应性Human
特异性The antibody detects endogenous levels of total CTNNAL1 protein.
免疫原类型peptide
免疫原描述Synthetic protein corresponding to residues near the C terminal of human CTNNAL1
基因/蛋白名称CTNNAL1
标记Unconjugated
别名ACRP; CLLP; alpha-CATU
数据库入口号Swiss-Prot:Q9UBT7
NCBI Gene ID:8727
NCBI Protein:BC117208
Uniprot
Q9UBT7
计算分子量82 kDa
浓度3.4mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:200-1:1000
Gel: 6%SDS-PAGE
£¬ Lysate: 40 ¦Ìg£¬ Lane:A431 cell lysate£¬
Primary antibody: 46548(CTNNAL1 Antibody) at dilution 1/500£¬
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution£¬
Exposure time: 1 minute
CTNNAL1 (catenin (cadherin-associated protein), alpha-like 1), also known as CLLP or alpha-CATU, is a 734 amino acid cytoplasmic peripheral membrane protein belonging to the vinculin/alpha-catenin family. Expressed at high levels in adrenal gland and present at lower levels in neural tissues, CTNNAL1 may be involved in the regulation of Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor 1 (RhoGEF p115). It is suggested that CTNNAL1 is down-regulated in pancreatic carcinoma undergoing differentiation and apoptosis. Existing as three isforms produced by alternative splicing events, CTNNAL1 may contribute to the wound repair and proliferation of human bronchial epithelial cells (HBEC).
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