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HER4 / ErbB4 Antibody #48301

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产品名称HER4 / ErbB4 Antibody

克隆号4G19

来源种属Mouse

纯化ProA affinity purified

应用WB, IP, IF, IHC(P), FCM

种属反应性Human;Mouse;Rat

免疫原描述Amino acids 1280-1308 at C-terminus of ErbB-4 of human origin.

标记Unconjugated

别名4ICD antibody
ALS19 antibody
Avian erythroblastic leukemia viral oncogene homolog 4 antibody
Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody
E4ICD antibody
EC 2.7.10.1 antibody
Erbb4 antibody
ERBB4 intracellular domain antibody
ERBB4_HUMAN antibody
HER 4 antibody
HER4 antibody
human epidermal growth factor receptor 4 antibody
Mer4 antibody
MGC138404 antibody
Oncogene ERBB4 antibody
p180erbB4 antibody
Proto-oncogene-like protein c-ErbB-4 antibody
Receptor protein tyrosine kinase erbB 4 precursor antibody
Receptor tyrosine protein kinase erbB 4 antibody
s80HER4 antibody
Tyrosine kinase type cell surface receptor HER4 antibody
Tyrosine kinase-type cell surface receptor HER4 antibody
v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody
v erb a erythroblastic leukemia viral oncogene homolog 4 antibody
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) antibody
V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 antibody
Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody
Verba erythroblastic leukemia viral oncogene homolog 4 antibody
VERBB2 antibody

数据库入口号Swiss-Prot#:Q15303

Uniprot Q15303

计算分子量180kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at 4˚C

应用详情

WB: 1:100-1:1,000
IHC: 1:50-500

IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
FC: 1 μg per 1 x 106 cells

Western blot analysis of ErbB-4 expression in control (A) and ErbB-4 transfected (B) NIH/3T3 whole cell lysates.
Intracellular FCM analysis of fixed and permeabilized control (green line histogram) and ErbB-4 transfected (solid orange histogram) NIH/3T3 cells. Dotted pink histogram represents the isotype control, normal mouse IgG2a.

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.

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操作手册

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu人
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk猴
  • Rb兔
  • B牛
  • D狗
  • P猪
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk鸡
;

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025-58868422

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